Kevin M. Rattigan

This study shows that AMPK senses NAD levels, with NAD binding to the gamma subunit and modulating AMPK activity, which affects metabolic pathways like mTORC1 and autophagy.

This paper identifies CD180 as a marker for chemoresistant stem-like blasts in KMT2A-rearranged paediatric AML, showing its absence on normal HSCs and its role as a therapeutic target.

This study develops a physiological CSF-like medium to culture CNS-ALL cells, revealing autophagy as a critical survival mechanism in the CNS niche.

The paper identifies L-pentahomoserine as a bacterial metabolite linked to better survival in esophageal cancer by supporting metabolic adaptations under nutrient stress.

This study identifies FGFR1 as a key driver of TMZ resistance in GBM through metabolic rewiring and cell cycle regulation, showing that FGFR1 inhibition restores TMZ sensitivity in preclinical models.