Spatial expression of an mRNA encoding Tie2-agonist in the capillary endothelium of the lung prevents pulmonary vascular leakage
Katrin Radloff, Birgitt Gutbier, Charlotte Maeve Dunne, Hanieh Moradian, Marko Schwestka, Manfred Gossen, Katharina Ahrens, Laura Kneller, Yadong Wang, Akanksha Moga, Leonidas Gkionis, Oliver Keil, Volker Fehring, Daniel Tondera, Klaus Giese, , Martin Witzenrath
This study evaluates a synthetic mRNA encoding a hyperactive Ang1 fusion protein to prevent pulmonary vascular leakage in lung injury models.
bioRxiv · Oct 12, 2022 · PreprintMolecular Biology