A high-throughput compound screen identifies multiple druggable targets in Plasmodium falciparum transmission stages
Leonie Seefeldt, Christin Gumpp, Olivia Carril, Jérôme Eberhardt, Sylwia D. Boltryk, Armin Passecker, Basil T. Thommen, Kleopatra Sifoniou, Christian Scheurer, Christoph Fischli, Deszoe Imre Babai, Amr Hamed Mahmoud, Leila T. Alexander, Steffen Renner, Armand Guiguemde, , Nicolas M. B. Brancucci
This study identifies three druggable targets in Plasmodium falciparum gametocytes using high-throughput screening and reveals resistance mechanisms for one compound.
bioRxiv · Sep 13, 2026 · PreprintMolecular Biology