Christin Gumpp

A high-throughput compound screen identifies multiple druggable targets in Plasmodium falciparum transmission stages

This study identifies three druggable targets in Plasmodium falciparum gametocytes using high-throughput screening and reveals resistance mechanisms for one compound.

Multidimensional in vitro assay for antimalarial combination testing and pharmacodynamic modeling - the MULT-i2 assay

The paper introduces a high-throughput in vitro assay for evaluating antimalarial drug combinations and their pharmacodynamic interactions, showing improved efficiency and resolution compared to existing methods.

Comparing the transmission blocking efficacy of Primaquine and Tafenoquine with in vivo pre-clinical models

This study compares the transmission blocking efficacy of primaquine and tafenoquine in vivo, finding tafenoquine more effective due to better pharmacokinetics beyond 24 hours.

An all-in-one pipeline for the in vitro discovery and in vivo testing of Plasmodium falciparum malaria transmission blocking drugs

The paper develops an in vitro and in vivo platform for testing malaria transmission-blocking drugs using engineered Plasmodium falciparum gametocytes and humanized mice.

Genetic validation of PfFKBP35 as an antimalarial drug target

This study genetically validates PfFKBP35 as a lethal target in Plasmodium falciparum, showing its role in ribosome homeostasis and revealing non-canonical modes of action for FK506.