Author

Hisashi Ishida

National Institutes for Quantum Science and TechnologyORCID 0000-0001-6383-1758Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1

Frequent Co-Authors

Hidetoshi KonoiD· 2 shared Asako Oguni· 1 shared Chikako Okada· 1 shared Kaori FukuzawaiD· 1 shared Keisuke HamadaiD· 1 shared Ko Sato· 1 shared Osamu NurekiiD· 1 shared Shunsuke KobayashiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Hidetoshi KonoORCID

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2 papers

Recent·Most cited

BiophysicsThe Journal of Physical Chemistry BPeer-reviewedSep 18, 2026

Impact of intercalators on the properties of DNA analyzed by molecular dynamics simulations

Hisashi Ishida, Hidetoshi Kono

This study uses MD simulations to analyze how DNA intercalators affect DNA conformation, revealing distinct intercalation patterns and their impact on mechanical properties.

DOI 10.1021/acs.jpcb.6c02297

DNA methylationmechanistic / dynamical model

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BiochemistryCell chemical biologyPeer-reviewedApr 15, 2026

Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1

Ko Sato, Hisashi Ishida, Toma Miyagishi…·Toru Sengoku

This paper reports cryo-EM structures of the HHV1 helicase-primase complex bound to DNA and inhibitors, revealing how these drugs block viral DNA replication by locking the helicase in an inactive conformation.

3 citationstop 1%

humancryo-EM

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