Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency
Jingliang Zhang, Muriel Eaton, Xiaoling Chen, Yuanrui Zhao, Shivam Kant, Brody A. Deming, Kothandaraman Harish, Huynhvi P. Nguyen, Yue Long Shu, Shirong Lai, Jiaxiang Wu, Zhefu Que, Kyle W. Wettschurack, Zaiyang Zhang, Tiange Xiao, , Yang Yang
This study shows that restoring NaV1.2 expression in adulthood rescues social deficits and improves neuronal signal-to-noise ratio in Scn2a-deficient mice.
bioRxiv · Mar 4, 2025 · PreprintNeuroscience