Author

Shivam Kant

Purdue University West Lafayette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Brody A. DemingiD· 2 shared Jingliang ZhangiD· 2 shared Manasi Suchit HalurkariD· 2 shared Nadia A. LanmaniD· 2 shared Xiaoling CheniD· 2 shared Yang YangiD· 2 shared Yuanrui Zhao· 2 shared Zaiyang ZhangiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Brody A. DemingORCID

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2 papers

Recent·Most cited

Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice

Zaiyang Zhang, Jingliang Zhang, Xiaoling Chen, Brody A. Deming, Shivam Kant, Purba Mandal, Harish Kothandaraman, Phillip J. SanMiguel, Manasi Suchit Halurkar, Akila D. Abeyaratna, Morgan J. Robinson, Yuanrui Zhao, Yuliia Vitko, Ronald Petrus Albertus Gaykema, Chongli Yuan, , Yang Yang

This paper shows that gene therapies can reduce absence seizures in DBA/2J mice with Scn2a deficiency by restoring NaV1.2 or introducing human KV1.1.

bioRxiv · Jun 3, 2025 · PreprintNeuroscience

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency

Jingliang Zhang, Muriel Eaton, Xiaoling Chen, Yuanrui Zhao, Shivam Kant, Brody A. Deming, Kothandaraman Harish, Huynhvi P. Nguyen, Yue Long Shu, Shirong Lai, Jiaxiang Wu, Zhefu Que, Kyle W. Wettschurack, Zaiyang Zhang, Tiange Xiao, , Yang Yang

This study shows that restoring NaV1.2 expression in adulthood rescues social deficits and improves neuronal signal-to-noise ratio in Scn2a-deficient mice.

bioRxiv · Mar 4, 2025 · PreprintNeuroscience