Shirong Lai

This paper develops a novel H2S2 donor, HPD1, which alleviates neuropathic pain by enhancing A-type potassium currents through a LIMK1-cofilin-Filamin A-Kv4.2 mechanism.

The paper identifies BN3 as a broad-spectrum agent that accelerates emergence from general anesthesia by targeting a VTA glutamatergic arousal circuit.

This study shows that restoring NaV1.2 expression in adulthood rescues social deficits and improves neuronal signal-to-noise ratio in Scn2a-deficient mice.

This study shows that severe NaV1.2 deficiency increases neuronal excitability in adult mice, challenging the current understanding of its role in autism and epilepsy.