Molecular BiologyNature MedicinePeer-reviewed
P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells
Robert J. Ihry, Kathleen A. Worringer, Max R. Salick…·Ajamete Kaykas
This study shows that CRISPR/Cas9 induces toxicity in human pluripotent stem cells, which is dependent on TP53 and hinders genome engineering.
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