Author

John S. Reece-Hoyes

ORCID 0000-0001-5251-5813Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Florian NigschiD· 2 shared Isabel SchmidtiD· 2 shared Ajamete KaykasiD· 1 shared Alison GouloisiD· 1 shared Amandine Rietsch· 1 shared Anca NeaguiD· 1 shared Andreas Hofmann· 1 shared Andrew I. MorrisoniD· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Florian NigschORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular BiologyMolecular CellPeer-reviewedJun 26, 2023

Convergence of multiple RNA-silencing pathways on GW182/TNRC6

Thomas Welte, Alison Goulois, Michael Beda Stadler…·Helge Großhans

The paper identifies TRIM71's mechanism of mRNA silencing through recruitment of TNRC6/GW182 and shows competition among silencing pathways.

28 citations

statistical model

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Molecular BiologybioRxivPreprintFeb 8, 2023

A novel HERC4-dependent glue degrader targeting STING

Merve Mutlu, Isabel Schmidt, Andrew I. Morrison…·Danilo Guerini

This paper identifies AK59 as a molecular glue degrader for STING, showing HERC4 is the key E3 ligase for its degradation and demonstrating efficacy against STING mutations.

DOI 10.1101/2023.02.08.527642

humanexperimental assay

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Molecular BiologyNature MedicinePeer-reviewedJun 8, 2018

P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells

Robert J. Ihry, Kathleen A. Worringer, Max R. Salick…·Ajamete Kaykas

This study shows that CRISPR/Cas9 induces toxicity in human pluripotent stem cells, which is dependent on TP53 and hinders genome engineering.

978 citationstop 1%

humanCRISPR screen

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