Author

Kristie E. Darrah

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Kara Anne BernsteiniD· 2 shared Arjun Kumar· 1 shared Bennett Van HouteniD· 1 shared Caleb M. StrattoniD· 1 shared Chelsea M. SmithiD· 1 shared Elena GlickiD· 1 shared Ella Roberts· 1 shared Gayatri Ganesan· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Kara Anne BernsteinORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJan 11, 2026

High-throughput mapping of 6,888 RAD51D variants identifies distinct biochemical functions needed for homologous recombination and olaparib response

Kristie E. Darrah, Shelby L. Hemker, Yashpal Rawal…·Kara Anne Bernstein

This paper maps 6,888 RAD51D variants to identify biochemical functions critical for homologous recombination and olaparib response, revealing key regions and mechanisms of variant impact.

1 citation

humanDNA methylation

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BiochemistryNature CommunicationsPeer-reviewedAug 21, 2024

The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA.

Sarah R Hengel, Katherine G. Oppenheimer, Chelsea M. Smith…·Kara Anne Bernstein

This study shows the Shu complex enhances RAD51 activity by stabilizing filaments and promoting RPA diffusion on ssDNA, with implications for cancer therapy.

14 citations

humanproteomics

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