Author

Chelsea M. Smith

University of North Carolina at Chapel HillORCID 0000-0001-8263-9817Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Afaf Helmy El-SagheeriD· 1 shared Andrew Marcel PregnalliD· 1 shared Anne‐Sophie WoznyiD· 1 shared Bennett Van HouteniD· 1 shared Brian E. EckenrothiD· 1 shared Carel FijeniD· 1 shared Dale A. RamsdeniD· 1 shared Dennis A. SimpsoniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCell Biology

Afaf Helmy El-SagheerORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 2, 2025

Hierarchical Coordination of Polymerase Theta and RAD51 Resolves Clustered Replication Fork Collapse

Chelsea M. Smith, Dennis A. Simpson, Paolo Guerra…·Gaorav P. Gupta

The paper shows Pol{theta} is recruited via RAD51 ubiquitylation to resolve clustered ICLs causing replication fork collapse in HR-proficient cells.

3 citations

mouseDNA methylation

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BiochemistryNature CommunicationsPeer-reviewedAug 21, 2024

The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA.

Sarah R Hengel, Katherine G. Oppenheimer, Chelsea M. Smith…·Kara Anne Bernstein

This study shows the Shu complex enhances RAD51 activity by stabilizing filaments and promoting RPA diffusion on ssDNA, with implications for cancer therapy.

14 citations

humanproteomics

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