Cancer BiologybioRxivPreprint
Netrin-1 regulates colorectal cancer stem cell self-renewal via a TFF3 dependent paracrine survival mechanism
Morgan Brisset, Kristina Radkova, Andréa Paradisi…·Frédéric Hollande
This study identifies the netrin-1/UNC5B/TFF3 axis as a regulator of colorectal cancer stem cell self-renewal and shows that targeting it with NP137 enhances chemotherapy efficacy in preclinical models.
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