Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: NLFTaum/h, an improved mouse model of Alzheimer's disease without mutations in MAPT
Sneha Desai, Jiongqiao La, Aya Balbaa, Elena Camporesi, Gunnar Brinkmalm, Kritika Goyal, Argyro Alatza, Jack I. Wood, Takshashila Tripathi, Sumi Bez, Nazar Stasyuk, Haady B. Hajar, Takashi Saito, Takaomi C. Saido, Henrik Zetterberg, , Frances A. Edwards
This paper introduces a new mouse model, NLFTaum/h, that shows ageing and amyloid-β can initiate tau pathology without MAPT mutations, revealing interactions between age, Aβ, and human tau.
bioRxiv · Nov 4, 2024 · PreprintNeuroscience