Sumi Bez

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau

This paper develops a scalable human neuronal model of 4R tauopathy with endogenous seed-competent tau for drug discovery.

Distinct mechanistic pathways of early tauopathy revealed by MAPT mutations

This study uses mouse models with tau mutations to show two distinct pathogenic mechanisms in tauopathies, with different progression patterns and responses to amyloid.

Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease

The paper identifies tau filaments within extracellular vesicles from Alzheimer's disease patients using mass spectrometry and cryo-electron microscopy.

Single MAPT knock-in mouse models of frontotemporal dementia for sharing with the neurodegenerative research community

The paper describes the development of triple MAPT mutation knock-in mice that exhibit early tau pathology and behavioral abnormalities, useful for studying frontotemporal dementia and related tauopathies.

Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: NLFTaum/h, an improved mouse model of Alzheimer's disease without mutations in MAPT

This paper introduces a new mouse model, NLFTaum/h, that shows ageing and amyloid-β can initiate tau pathology without MAPT mutations, revealing interactions between age, Aβ, and human tau.