Sneha Desai

The paper identifies gene expression changes in microglia around Aβ plaques in human Alzheimer's disease tissue and finds cross-species concordance with mouse data.

This paper introduces a new mouse model, NLFTaum/h, that shows ageing and amyloid-β can initiate tau pathology without MAPT mutations, revealing interactions between age, Aβ, and human tau.

This paper uses isotope-encoded mass spectrometry imaging and single plaque transcriptomics to track Aβ plaque maturation and its impact on synaptic function and toxicity in Alzheimer's disease.

The paper shows that Trem2 gene expression in microglia is upregulated only when they contact plaques, and this effect is reduced by the Trem2R47H mutation.