Synaptic plasticity in human thalamocortical assembloids
Mary H. Patton, Kristen T. Thomas, Ildar T. Bayazitov, Kyle D. Newman, Nathan B. Kurtz, Camenzind G. Robinson, Cody A. Ramirez, Alexandra J. Trevisan, Jay B. Bikoff, Sam Peters, Shondra M. Pruett‐Miller, Yanbo Jiang, Andrew B. Schild, Anjana Nityanandam, Stanislav S. Zakharenko
This paper demonstrates that thalamocortical assembloids formed from human organoids exhibit functional glutamatergic synapses with short-term plasticity and distinct long-term potentiation and depression mechanisms compared to rodents.
Cell Reports · Jul 16, 2024Peer-reviewedNeuroscience