Schizophrenia-associated 22q11.2 deletion elevates striatal acetylcholine and disrupts thalamostriatal projections to produce amotivation in mice
Mary H. Patton, Brett J.W. Teubner, Kristen T. Thomas, Sharon L. Freshour, Alexandra J. Trevisan, Andrew B. Schild, Cody A. Ramirez, Jay B. Bikoff, Stanislav S. Zakharenko
This study identifies striatal hypercholinergic state and thalamostriatal disruption as causes of amotivation in a 22q11DS mouse model.
bioRxiv · Jun 20, 2025 · PreprintNeuroscience