IL-8 Instructs Macrophage Identity in Lateral Ventricle Contacting Glioblastoma
Stephanie Medina, Asa A. Brockman, Claire E. Cross, Madeline Hayes, Bret C. Mobley, Akshitkumar M. Mistry, Silky Chotai, Kyle D. Weaver, Reid C. Thompson, Lola Blackwell Chambless, Rebecca A. Ihrie, Jonathan Michael Irish
This study identifies IL-8 as a key factor instructing macrophage identity in glioblastoma, showing IL-8 is necessary for generating CD32+ M_IL-8 macrophages in tumors contacting the lateral ventricle.
bioRxiv · Mar 29, 2024 · PreprintCancer Biology