EBF1 controls an embryonic artery-forming niche that reactivates in pulmonary arterial hypertension
Wen Tian, Ting-Hsuan Wu, Shenbiao Gu, Seunghee Lee, Hanqiu Zhao, Adam Andruska, Kyle K. Song, Jason Chang, Cerianne Huang, Ryan Vinh, Dongeon Kim, Yu Zhu, Evan Bao, Stuti Agarwal, Dan Yi, , Mark Robert Nicolls
This study identifies EBF1 as a regulator of embryonic artery formation and shows its reactivation in pulmonary arterial hypertension drives pathological vascular remodeling.
bioRxiv · May 2, 2025 · PreprintDevelopmental Biology