Mark Robert Nicolls

This study identifies CES1 deficiency as a driver of metabolic reprogramming and endothelial dysfunction in pulmonary arterial hypertension, showing its role in lipid metabolism and oxidative stress.

This study identifies EBF1 as a regulator of embryonic artery formation and shows its reactivation in pulmonary arterial hypertension drives pathological vascular remodeling.

The paper shows that ultrasound neuromodulation of the spleen reduces experimental pulmonary hypertension by improving hemodynamics and reducing inflammation.