Modeling Cancer Genomic Data in Yeast Reveals Selection Against ATM Function During Tumorigenesis
Marcel Hohl, Aditya Mojumdar, Sarem Hailemariam, Vitaly Kuryavyi, Fiorella Ghisays, Kyle Sorenson, Matthew Chang, Barry S. Taylor, Dinshaw J. Patel, Peter Burgers, Jennifer A. Cobb, John H.J. Petrini
The paper models mutations in the Mre11 complex in yeast to show that defects in ATM signaling, rather than DNA repair, are more critical for tumor suppression.
PLoS Genetics · Mar 18, 2020Peer-reviewedGenetics