Author

Matthew Chang

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-9486-1228Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Matthew Chang1 paper · Cornell University

Biology Disciplines

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Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Approach:statistical model· 1 Assay:whole-exome sequencing· 1 Organism:yeast· 1

Frequent Co-Authors

Aditya MojumdariD· 1 shared Alexander E. DaviesiD· 1 shared Amy Gross· 1 shared Barry S. TayloriD· 1 shared Carol M. R. Halsey· 1 shared Dinshaw J. PateliD· 1 shared Elise C. ManaloiD· 1 shared Fiorella GhisaysiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenetics

Aditya MojumdarORCID

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2 papers

Recent·Most cited

Spatially coordinated RTK-ERK signaling dynamics shape osteosarcoma single-cell drug response in the lung microenvironment

Rawan Makkawi, Carol M. R. Halsey, Vaibhav Murthy, Elise C. Manalo, Hugo Cros, Xin Yi, Jessie May Cartier, Matthew Chang, Mark R. Flory, Kelly Guptell, Amy Gross, Ryan David Roberts, Jeremy Copperman, Alexander E. Davies

This study identifies FGFR-ERK signaling as a driver of adaptive resistance in osteosarcoma lung metastases and shows that combinatorial RTK inhibition enhances MCL1 inhibitor efficacy.

bioRxiv · Oct 2, 2026 · PreprintCancer Biology

Modeling Cancer Genomic Data in Yeast Reveals Selection Against ATM Function During Tumorigenesis

Marcel Hohl, Aditya Mojumdar, Sarem Hailemariam, Vitaly Kuryavyi, Fiorella Ghisays, Kyle Sorenson, Matthew Chang, Barry S. Taylor, Dinshaw J. Patel, Peter Burgers, Jennifer A. Cobb, John H.J. Petrini

The paper models mutations in the Mre11 complex in yeast to show that defects in ATM signaling, rather than DNA repair, are more critical for tumor suppression.

PLoS Genetics · Mar 18, 2020Peer-reviewedGenetics