Author

L. A. Akslen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. Askeland· 4 shared G. Knutsvik· 4 shared S. Aziz· 3 shared B. Davidsen· 2 shared D. Kleftogiannis· 2 shared D. R. Bielenberg· 2 shared D. Sim· 2 shared E. Wik· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersCancer Biology

C. Askeland

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Age-related phenotypes in breast cancer: a population- based study

A. Svanoe, R. Humlevik, G. Knutsvik, A. K. M. Sele, C. Askeland, L. M. Ingebriktsen, U. Hugaas, A. B. Kvamme, A. F. Tegnander, K. Kruger, B. Davidsen, E. A. Hoivik, T. Aas, I. M. Stefansson, L. A. Akslen, E. Wik

This study examines age-related differences in breast cancer biology, finding that younger patients have more aggressive tumors with higher proliferation and stem-like features.

bioRxiv · May 22, 2023Pathology

Global and single-cell proteomics view of the co-evolution between neural progenitors and breast cancer cells in a co-culture model

O. V. Bjoernstad, M. C. Fernandez, K. Finne, I. Winge, C. Askeland, J. B. Arnes, G. Knutsvik, D. Kleftogiannis, J. A. Paulo, L. A. Akslen, H. Vethe

The paper investigates neural progenitor cells in breast cancer using proteomics and co-culture models, finding DCX+/NFL+ cells in tumors and their role in aggressive cancer phenotypes.

bioRxiv · May 3, 2023Cancer Biology

Single-cell mapping links neurogenesis and angiogenesis in aggressive breast cancer

E. Wik, S. Aziz, K. Finne, D. Kleftogiannis, C. Askeland, G. Knutsvik, I. Winge, K. Kruger, A. A. Svanoe, E. Birkeland, S. Kjolle, B. Davidsen, T. Aas, I. M. Stefansson, H. Vethe, L. A. Akslen

The paper links neurogenesis and angiogenesis in aggressive breast cancer using single-cell spatial mapping and multi-omics data, showing a neuro-angiogenic signature associated with poor prognosis.

bioRxiv · Jan 28, 2022 · PreprintCancer Biology

PRSS2 stimulates tumor growth by remodeling the TME via repression of Tsp1

L. Sui, S. Wang, D. Ganguly, T. El Rayes, C. Askeland, A. Borretzen, K. Zhou, D. Sim, O. J. Halvorsen, G. Knutsvik, S. Aziz, S. Haukaas, W. D. Foulkes, D. R. Bielenberg, A. Ziemys, , R. S. Watnick

This study identifies PRSS2 as a factor that represses Tsp-1 in the tumor microenvironment by binding to LRP1, promoting tumor growth.

bioRxiv · Mar 23, 2021 · PreprintCancer Biology

Notch1 regulates breast cancer stem cell function via a non-canonical cleavage-independent pathway

L. Sui, S. Wang, R. K. Rodriguez, D. Sim, N. Bhattacharya, A. L. Blois, T. Schlaeger, S. Chen, S. Aziz, M. S. Rogers, D. R. Bielenberg, L. A. Akslen, R. S. Watnick

This study identifies a non-canonical Notch1 pathway that represses SIRT1 to drive tumor initiation and chemoresistance in breast cancer stem cells.

bioRxiv · Feb 28, 2020 · PreprintCancer Biology