N. Bhattacharya

Non-canonical NF-κB signaling promotes intestinal inflammation by restraining the tolerogenic β-catenin-Raldh2 axis in dendritic cells

Randomized gates eliminate bias in sort-seq assays

The paper introduces randomized sorting in sort-seq assays to eliminate systematic bias, validated through simulation and experiments, and extends the method for variance estimation and multi-bin sorting.

Gene expression based inference of drug resistance in cancer

This study uses gene expression data and machine learning to predict drug resistance in cancer by analyzing pathway activity patterns rather than gene expression levels alone.

FLIP: Benchmark tasks in fitness landscape inference for proteins

FLIP introduces a benchmark for fitness landscape inference in proteins, focusing on function prediction and model generalization in protein engineering scenarios.

Notch1 regulates breast cancer stem cell function via a non-canonical cleavage-independent pathway

This study identifies a non-canonical Notch1 pathway that represses SIRT1 to drive tumor initiation and chemoresistance in breast cancer stem cells.

Necrotizing enterocolitis is preceded by increased gut bacterial replication, Klebsiella, and fimbriae-encoding bacteria that may stimulate TLR4 receptors

The paper identifies microbial features predictive of necrotizing enterocolitis (NEC) in premature infants using metagenomic analysis and machine learning.

Differences in the path to exit the ribosome across the three domains of life

The paper compares ribosome exit tunnel structures across bacteria, archaea, and eukarya to understand geometric and sequence conservation patterns and their implications for translation dynamics.