Author

L. A. Birnbaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 3 Approach:experimental assay· 2 Approach:deep learning· 1 Assay:proteomics· 1

Frequent Co-Authors

E. C. Dreaden· 3 shared B. Uricoli· 2 shared D. DeRyckere· 2 shared D. K. Graham· 2 shared H. Fu· 2 shared H. Zecca· 2 shared J. Jain· 2 shared J. M. Kelvin· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

E. C. Dreaden

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Author profile →

3 papers

Recent·Most cited

Constitutively synergistic multiagent drug formulations targeting MERTK, FLT3, and BCL-2 for treatment of AML

J. M. Kelvin, J. Jain, A. Thapa, M. Qui, L. A. Birnbaum, S. G. Moore, H. Zecca, R. J. Summers, E. Costanza, B. Uricoli, X. Wang, N. T. Jui, H. Fu, Y. Du, D. DeRyckere, , E. C. Dreaden

The paper develops a nanoscale combination drug formulation targeting MERTK, FLT3, and BCL-2 to treat AML, showing improved synergistic responses in vitro and in patient samples.

bioRxiv · Mar 13, 2023 · PreprintBioengineering

Multicolor Light-Induced Immune Activation via Polymer Photocaged Cytokines

L. A. Birnbaum, E. C. Sullivan, P. Do, B. Uricoli, C. C. Porter, C. J. Henry, E. C. Dreaden

This paper develops a method to control cytokine activity using light, enabling spatial and temporal regulation of immune responses ex vivo.

bioRxiv · Oct 3, 2022Bioengineering

Screening and Development of Constitutively Synergistic Combination Drug Formulations for T Cell Acute Lymphoblastic Leukemia

J. M. Kelvin, D. Y. Zhang, E. K. Williams, S. G. Moore, L. A. Birnbaum, H. Zecca, X. Wang, J. Jain, M. Qui, N. T. Jui, H. Fu, Y. Du, M. L. Kemp, W. A. Lam, D. DeRyckere, , E. C. Dreaden

The paper identifies synergistic drug combinations for T-ALL using high-throughput screens and develops lipid nanoparticle formulations that maintain drug synergy and improve anti-leukemic activity.

bioRxiv · Sep 21, 2022 · PreprintBioengineering