W. A. Lam

HIGH THROUGHPUT QUANTITATION OF HUMAN NEUTROPHIL RECRUITMENT AND FUNCTIONAL RESPONSES IN AN AIR-BLOOD BARRIER ARRAY

The paper develops a high-throughput assay to study neutrophil recruitment and function in an air-blood barrier array, showing improved throughput and sample efficiency compared to existing methods.

Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma

This study develops a 3D bone marrow-on-a-chip model to investigate interactions between CAR-T cells and multiple myeloma cells in different niches and assess therapeutic responses.

Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders

The paper uses computational simulations to show that marginated aberrant red blood cells generate vascular stress fluctuations, potentially causing endothelial damage in blood disorders.

Screening and Development of Constitutively Synergistic Combination Drug Formulations for T Cell Acute Lymphoblastic Leukemia

The paper identifies synergistic drug combinations for T-ALL using high-throughput screens and develops lipid nanoparticle formulations that maintain drug synergy and improve anti-leukemic activity.

USP11 promotes endothelial apoptosis-resistance in pulmonary hypertension by deubiquitinating HINT3

This study identifies USP11 as a deubiquitinase that stabilizes HINT3, promoting endothelial apoptosis-resistance in pulmonary hypertension.

PPARγ/ETV2 Axis Regulates Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

This study identifies the PPARγ/ETV2 axis as a novel pathway that suppresses endothelial-to-mesenchymal transition in pulmonary hypertension.