Cancer BiologybioRxiv
Increased CaMKK2 expression is an adaptive response that maintains the fitness of tumor-infiltrating natural killer cells
P. K. Juras, L. Racioppi, D. Mukherjee…·D. P. McDonnell
This study shows that CaMKK2 in tumor-infiltrating NK cells suppresses apoptosis and promotes proliferation, with its expression driven by intracellular lactic acid.
DOI 10.1158/2326-6066.cir-22-0391