Author

P. K. Juras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C.-Y. Chang· 2 shared D. Mukherjee· 2 shared D. P. McDonnell· 2 shared S. Artham· 2 shared B. Chakraborty· 1 shared C. N. Haines· 1 shared F. H. Lau· 1 shared J. A. Freedman· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

C.-Y. Chang

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2 papers

Recent·Most cited

Ca2+/Calmodulin Dependent Protein Kinase Kinase-2 (CaMKK2) promotes Protein Kinase G (PKG)-dependent actin cytoskeletal assembly to increase tumor metastasis

D. Mukherjee, R. A. Previs, C. N. Haines, M. Al Abo, P. K. Juras, K. C. Strickland, B. Chakraborty, S. Artham, R. Whitaker, K. L. Hebert, J. Fontenot, S. R. Patierno, J. A. Freedman, F. H. Lau, M. Burow, , D. P. McDonnell

This study identifies CaMKK2 as a driver of tumor metastasis through a novel signaling pathway involving PDE1A, PKG1, and VASP, suggesting it as a therapeutic target for TNBC and HGSOC.

bioRxiv · Apr 17, 2023 · PreprintCancer Biology

Increased CaMKK2 expression is an adaptive response that maintains the fitness of tumor-infiltrating natural killer cells

P. K. Juras, L. Racioppi, D. Mukherjee, S. Artham, X. Gao, L. A. D'Agostino, C.-Y. Chang, D. P. McDonnell

This study shows that CaMKK2 in tumor-infiltrating NK cells suppresses apoptosis and promotes proliferation, with its expression driven by intracellular lactic acid.

bioRxiv · May 18, 2022Cancer Biology