Author

D. P. McDonnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C.-Y. Chang· 3 shared D. Mukherjee· 3 shared S. Artham· 3 shared L. Racioppi· 2 shared P. K. Juras· 2 shared A. Binte Mohamed Bashir· 1 shared A. Means· 1 shared B. Chakraborty· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

C.-Y. Chang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Breast cancer cells can recognize and respond to different levels of progestins to achieve different phenotypic outputs

E. L. Dolan, R. Safi, C.-Y. Chang, H. E. Eaton, S. Krishnan, R. Safi, P. Watkinson, H. Long, Y. Xie, M. Brown, S. K. Murphy, D. P. McDonnell

This study shows that breast cancer cells respond differently to low and high levels of progestins, with low levels promoting proliferation through specific molecular mechanisms.

bioRxiv · Oct 13, 2023 · PreprintCancer Biology

Ca2+/Calmodulin Dependent Protein Kinase Kinase-2 (CaMKK2) promotes Protein Kinase G (PKG)-dependent actin cytoskeletal assembly to increase tumor metastasis

D. Mukherjee, R. A. Previs, C. N. Haines, M. Al Abo, P. K. Juras, K. C. Strickland, B. Chakraborty, S. Artham, R. Whitaker, K. L. Hebert, J. Fontenot, S. R. Patierno, J. A. Freedman, F. H. Lau, M. Burow, , D. P. McDonnell

This study identifies CaMKK2 as a driver of tumor metastasis through a novel signaling pathway involving PDE1A, PKG1, and VASP, suggesting it as a therapeutic target for TNBC and HGSOC.

bioRxiv · Apr 17, 2023 · PreprintCancer Biology

SGC-CAMKK2-1: A chemical probe for CAMKK2

C. I. Wells, Y. Liang, T. L. Pulliam, C. Lin, D. Awad, B. Eduful, S. O Byrne, M. A. Hossain, C. Catta-Preta, P. Zonzini Ramos, O. Gileadi, C. Gileadi, R. M. Counago, B. Stork, C. G. Langendorf, , D. H. Drewry

This paper introduces SGC-CAMKK2-1, a selective chemical probe for CAMKK2, demonstrating its potential as a tool to study the therapeutic benefits of CAMKK2 inhibition.

Cells · Jan 11, 2023Peer-reviewedCancer Biology

Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signaling

X. X. Huang, L. M. Ng, P.-H. Lee, P. Guan, M. J. Chow, A. Binte Mohamed Bashir, M. Lau, K. Tan, Z. Li, J. Chan, J. Hong, S. R. Ng, H. L. Teo, D. Rhodes, P. Tan, , B. T. Teh

This study examines how mutations in the RAR ligand binding domain affect retinoic acid signaling and tumorigenesis in breast fibroepithelial tumors.

bioRxiv · Dec 1, 2022 · PreprintCancer Biology

Increased CaMKK2 expression is an adaptive response that maintains the fitness of tumor-infiltrating natural killer cells

P. K. Juras, L. Racioppi, D. Mukherjee, S. Artham, X. Gao, L. A. D'Agostino, C.-Y. Chang, D. P. McDonnell

This study shows that CaMKK2 in tumor-infiltrating NK cells suppresses apoptosis and promotes proliferation, with its expression driven by intracellular lactic acid.

bioRxiv · May 18, 2022Cancer Biology

A new chemotype of chemically tractable nonsteroidal estrogens based on a thienopyrimidine core.

V. R. Sammeta, J. D. Norris, S. Artham, C. D. Torrice, J. Byemerwa, C. Joiner, S. W. Fanning, D. P. McDonnell, T. M. Willson

The paper identifies a new chemotype of nonsteroidal estrogens based on a thienopyrimidine core through targeted screening and structure-guided optimization.

bioRxiv · Apr 15, 2022Cell Biology