Author

L. A. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Meller· 1 shared B. Al-Rawashdeh· 1 shared B. Merriman· 1 shared B. Novak· 1 shared B. Reversade· 1 shared C. C. Kuhn· 1 shared E. J. Wagner· 1 shared G. R. Bowman· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. Meller

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Author profile →

2 papers

Recent·Most cited

Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

A. Meller, J. M. Lotthammer, L. G. Smith, B. Novak, L. A. Lee, C. C. Kuhn, L. Greenberg, L. A. Leinwand, M. J. Greenberg, G. R. Bowman

This paper shows that the probability of cryptic pocket opening in myosin motor domains predicts drug specificity and affinity, using molecular dynamics simulations and Markov state models.

bioRxiv · Sep 5, 2022Biophysics

INTS13 Mutations Causing a Developmental Ciliopathy Disrupt Integrator Complex Assembly

L. G. Mascibroda, M. Shboul, N. D. Elrod, L. Colleaux, H. Hamamy, K.-L. Huang, N. J. Peart, M. K. Singh, H. Lee, B. Merriman, J. N. Jodoin, L. A. Lee, B. Al-Rawashdeh, O. Ababneh, M. El-Khateeb, , E. J. Wagner

This study identifies mutations in INTS13 causing a ciliopathy by disrupting Integrator complex assembly and ciliogenesis.

bioRxiv · Jul 20, 2020 · PreprintBiochemistry