Author

C. C. Kuhn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Martinez-Sanchez· 1 shared A. Meller· 1 shared B. Novak· 1 shared C. Biertumpfel· 1 shared G. R. Bowman· 1 shared J. M. Lotthammer· 1 shared J. Takagi· 1 shared L. A. Lee· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. Martinez-Sanchez

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Author profile →

2 papers

Recent·Most cited

Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 Spike protein

C. C. Kuhn, N. Basnet, S. Bodakuntla, P. Alvarez- Brecht, S. Nichols, A. Martinez-Sanchez, L. Agostini, Y.-M. Soh, J. Takagi, C. Biertumpfel, N. Mizuno

This study observes SARS-CoV-2 Spike protein-induced platelet deformation and activation using cryo-ET and live imaging, identifying integrin vβ3 as a binding target.

bioRxiv · Nov 22, 2022Cell Biology

Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

A. Meller, J. M. Lotthammer, L. G. Smith, B. Novak, L. A. Lee, C. C. Kuhn, L. Greenberg, L. A. Leinwand, M. J. Greenberg, G. R. Bowman

This paper shows that the probability of cryptic pocket opening in myosin motor domains predicts drug specificity and affinity, using molecular dynamics simulations and Markov state models.

bioRxiv · Sep 5, 2022Biophysics