M. K. Singh

A constricted mitochondrial morphology optimizes respiration.

The paper identifies a new mitochondrial morphology in yeast called Ringo that enhances respiration by ensuring proper OXPHOS complex assembly.

A Plasmodium falciparum MORC protein complex modulates epigenetic control of gene expression through interaction with heterochromatin.

This study identifies PfMORC as a chromatin-associated protein in Plasmodium falciparum that modulates gene expression through interactions with chromatin remodelers and transcription factors.

A diet-independent zebrafish model for NAFLD recapitulates patient lipid profiles and offers a system for small molecule screening

This study develops a diet-independent zebrafish model of NAFLD that mimics patient lipid profiles and demonstrates responsiveness to Rosiglitazone treatment.

Semaphorin3F reduces vascular endothelial and smooth muscle cell PI3K activation and decreases neointimal plaque formation

This study shows that Semaphorin3F reduces PI3K activation in vascular endothelial and smooth muscle cells, leading to decreased neointimal plaque formation and increased plaque stability.

Heterodimers of functionally divergent ARF-GEF paralogues prevented by self-interacting dimerisation domain

The paper shows that GNOM and GNL1 ARF-GEFs form homodimers but not heterodimers due to self-interacting dimerisation domains, preventing potentially harmful interactions.

PRAK-03202: A triple antigen VLP vaccine candidate against SARS CoV-2

This paper develops a triple antigen VLP vaccine candidate, PRAK-03202, against SARS-CoV-2 and shows it induces neutralizing antibodies and Th1 immune responses in mice.

INTS13 Mutations Causing a Developmental Ciliopathy Disrupt Integrator Complex Assembly

This study identifies mutations in INTS13 causing a ciliopathy by disrupting Integrator complex assembly and ciliogenesis.

ARF1 dimerization is essential for vesicle trafficking and dependent on activation by ARF-GEF dimers in Arabidopsis