Author

L. Abernathy-Close

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

I. L. Bergin· 2 shared K. C. Vendrov· 2 shared V. B. Young· 2 shared A. Standke· 1 shared K. L. Sovacool· 1 shared M. G. Dieterle· 1 shared M. R. Barron· 1 shared P. D. Schloss· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

I. L. Bergin

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2 papers

Recent·Most cited

Intestinal inflammation reversibly alters the microbiota to drive susceptibility to Clostridioides difficile colonization in a mouse model of colitis

M. R. Barron, K. L. Sovacool, L. Abernathy-Close, K. C. Vendrov, A. Standke, I. L. Bergin, P. D. Schloss, V. B. Young

This study shows that intestinal inflammation in a mouse model alters microbiota composition, increasing susceptibility to C. difficile colonization, and that reducing inflammation restores colonization resistance.

bioRxiv · Apr 7, 2022Microbiology

Aging dampens the intestinal innate immune response during Clostridioides difficile infection and is associated with altered intestinal eosinophil mobilization

L. Abernathy-Close, M. G. Dieterle, K. C. Vendrov, I. L. Bergin, V. B. Young

This study shows that aging impairs the intestinal innate immune response to C. difficile infection, leading to increased disease severity and altered eosinophil mobilization.

bioRxiv · Jan 2, 2020Immunology