V. B. Young

Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence.

The paper identifies that longer inverted repeats in the flagellar switch region of C. difficile RT027 strains correlate with greater virulence and phenotypic heterogeneity in flagellar gene expression.

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile

This study identifies a 69 base-pair deletion in the cdtR gene that attenuates virulence in ST1 C. difficile strains without affecting colonization.

Neutrophils prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal Salmonella enterica serovars

This study investigates how human neutrophils modulate host responses to two nontyphoidal Salmonella serovars using intestinal organoids and transcriptomics.

Vaginal microbiota of adolescents and their mothers: A preliminary study of vertical transmission and persistence

This study examines the vaginal microbiota of adolescent daughters and their mothers, finding that vaginal delivery is associated with similar microbiota between mothers and daughters.

Differences in Gut Microbiota Assembly Alter Its Ability to Metabolize Dietary Polysaccharides and Resist Clostridioides difficile Colonization

This study shows that diluted gut microbiota lose resistance to C. difficile and inulin metabolism, linking butyrate-producing taxa to colonization resistance.

Intestinal inflammation reversibly alters the microbiota to drive susceptibility to Clostridioides difficile colonization in a mouse model of colitis

This study shows that intestinal inflammation in a mouse model alters microbiota composition, increasing susceptibility to C. difficile colonization, and that reducing inflammation restores colonization resistance.

The gut bacterial community potentiates Clostridioides difficile infection severity

This study shows that gut bacterial communities influence the severity of Clostridioides difficile infections in mice, with certain bacterial groups linked to more or less severe outcomes.

The Food Additive Xanthan Gum Drives Adaptation of the Human Gut Microbiota

This study shows that xanthan gum, a common food additive, promotes the adaptation of the human gut microbiota by enabling a novel degradation pathway in an uncultured Ruminococcaceae bacterium and facilitating cross-feeding by Bacteroides species.

Protection from lethal Clostridioides difficile infection via intraspecies competition for co-germinant

This study shows pre-colonization with a less virulent C. difficile strain reduces germination of a lethal strain by limiting glycine availability, offering a mechanism for protective intraspecies competition.

Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids

This study compares host transcriptional responses to typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids, revealing distinct gene expression patterns and immune responses.

Salmonella enterica serovar Typhimurium SPI-1 and SPI-2 shape the transcriptional landscape of epithelial cells in a human intestinal organoid model system

This study uses human intestinal organoids to investigate how Salmonella SPI-1 and SPI-2 T3SSs influence host transcriptional responses during infection, revealing distinct and overlapping roles in inflammation and cell cycle suppression.

Intestinal inflammation and altered gut microbiota associated with inflammatory bowel disease renders mice susceptible to Clostridioides difficile colonization and infection

This study shows that intestinal inflammation and altered gut microbiota in IBD make mice susceptible to C. difficile colonization and infection, highlighting the role of IBD-induced microbiota in disease severity.

Loss of RpoS results in attenuated Escherichia coli colonization of human intestinal organoids and a competitive disadvantage within the germ-free mouse intestine

This study shows that E. coli lacking RpoS has reduced colonization ability in human intestinal organoids but not in germ-free mice, indicating different stress environments in these models.

A plasmid locus associated with Klebsiella clinical infections encodes a microbiome-dependent gut fitness factor

The paper identifies a plasmid-encoded ter operon in Klebsiella pneumoniae that functions as a microbiome-dependent gut fitness factor, enhancing colonization in the presence of specific gut microbiota.

Dietary xanthan gum alters antibiotic efficacy against the murine gut microbiota and attenuates Clostridioides difficile colonization

This study shows that dietary xanthan gum reduces C. difficile colonization in mice by maintaining gut microbiota diversity and abundance during antibiotic treatment.

Aging dampens the intestinal innate immune response during Clostridioides difficile infection and is associated with altered intestinal eosinophil mobilization

This study shows that aging impairs the intestinal innate immune response to C. difficile infection, leading to increased disease severity and altered eosinophil mobilization.

Effects of the copper IUD on composition of the vaginal microbiota in the olive baboon

This study examines the effects of copper IUD insertion, use, and removal on the vaginal microbiota and physiology of olive baboons, finding no significant microbiome changes during use but perturbations after removal.

Temporal Gut Microbial Changes Predict Recurrent Clostridium difficile in Patients with and without Ulcerative Colitis

The paper identifies microbial features predicting recurrent Clostridium difficile infection in UC patients and non-UC individuals using 16S rRNA sequencing and logistic regression models.

Evaluation of Bacteria Detected in Both Urine and Open Wounds in Nursing Facility Residents

This study compares bacterial colonization in urine and open wounds of nursing home residents, finding shared species like Enterococcus faecalis and Escherichia coli.

The gut microbiota is associated with clearance of Clostridium difficile infection independent of adaptive immunity

This study shows that the gut microbiota, not adaptive immunity, is key for clearing C. difficile infection in mice, using Random Forest analysis to identify predictive bacterial members.

Clostridium difficile alters the structure and metabolism of distinct cecal microbiomes during initial infection to promote sustained colonization

This study shows that C. difficile infection alters gut microbiome structure and metabolism in mice pretreated with specific antibiotics, promoting persistent colonization.

Clostridium difficile colonizes alternative nutrient niches during infection across distinct murine gut microbiomes

This study shows C. difficile adapts its metabolism to different gut environments caused by antibiotic pretreatment, preferring nitrogen-containing carbon sources and host-derived glycans.

Inter-individual Recovery Of The Microbiota And Metabolome Over Time Following Fecal Microbiota Transplantation In Patients With Recurrent Clostridium difficile Infection

This study examines microbiota and metabolome recovery in patients with recurrent CDI after FMT, identifying microbial associations with metabolite changes and individualized recovery patterns.