M. R. Barron

Intestinal inflammation reversibly alters the microbiota to drive susceptibility to Clostridioides difficile colonization in a mouse model of colitis

This study shows that intestinal inflammation in a mouse model alters microbiota composition, increasing susceptibility to C. difficile colonization, and that reducing inflammation restores colonization resistance.

Protection from lethal Clostridioides difficile infection via intraspecies competition for co-germinant

This study shows pre-colonization with a less virulent C. difficile strain reduces germination of a lethal strain by limiting glycine availability, offering a mechanism for protective intraspecies competition.

Intestinal inflammation and altered gut microbiota associated with inflammatory bowel disease renders mice susceptible to Clostridioides difficile colonization and infection

This study shows that intestinal inflammation and altered gut microbiota in IBD make mice susceptible to C. difficile colonization and infection, highlighting the role of IBD-induced microbiota in disease severity.

Loss of RpoS results in attenuated Escherichia coli colonization of human intestinal organoids and a competitive disadvantage within the germ-free mouse intestine

This study shows that E. coli lacking RpoS has reduced colonization ability in human intestinal organoids but not in germ-free mice, indicating different stress environments in these models.