K. C. Vendrov

Intestinal inflammation reversibly alters the microbiota to drive susceptibility to Clostridioides difficile colonization in a mouse model of colitis

This study shows that intestinal inflammation in a mouse model alters microbiota composition, increasing susceptibility to C. difficile colonization, and that reducing inflammation restores colonization resistance.

Protection from lethal Clostridioides difficile infection via intraspecies competition for co-germinant

This study shows pre-colonization with a less virulent C. difficile strain reduces germination of a lethal strain by limiting glycine availability, offering a mechanism for protective intraspecies competition.

Intestinal inflammation and altered gut microbiota associated with inflammatory bowel disease renders mice susceptible to Clostridioides difficile colonization and infection

This study shows that intestinal inflammation and altered gut microbiota in IBD make mice susceptible to C. difficile colonization and infection, highlighting the role of IBD-induced microbiota in disease severity.

Dietary xanthan gum alters antibiotic efficacy against the murine gut microbiota and attenuates Clostridioides difficile colonization

This study shows that dietary xanthan gum reduces C. difficile colonization in mice by maintaining gut microbiota diversity and abundance during antibiotic treatment.

Aging dampens the intestinal innate immune response during Clostridioides difficile infection and is associated with altered intestinal eosinophil mobilization

This study shows that aging impairs the intestinal innate immune response to C. difficile infection, leading to increased disease severity and altered eosinophil mobilization.

The gut microbiota is associated with clearance of Clostridium difficile infection independent of adaptive immunity

This study shows that the gut microbiota, not adaptive immunity, is key for clearing C. difficile infection in mice, using Random Forest analysis to identify predictive bacterial members.