Promoting Fc-Fc interactions between anti-capsular antibodies provides strong complement-dependent immune protection against Streptococcus pneumoniae
L. Aguinagalde, M. A. den Boer, S. Castenmiller, S. Zwarthoff, C. J. C. de Haas, P. Aerts, F. J. Beurskens, J. Schuurman, A. J. R. Heck, K. V. Kessel, S. Rooijakkers
This paper shows that modifying anti-capsular antibodies to enhance hexamerization improves complement activation and immune protection against Streptococcus pneumoniae.
bioRxiv · Jan 21, 2022Microbiology