Author

M. A. den Boer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

A. J. R. Heck· 4 shared C. J. C. de Haas· 2 shared F. J. Beurskens· 2 shared J. Schuurman· 2 shared P. Aerts· 2 shared S. H. M. Rooijakkers· 2 shared S. Tamara· 2 shared A. Barendregt· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersImmunology

A. J. R. Heck

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4 papers

Recent·Most cited

ImmunologybioRxivMay 22, 2023

Direct mass spectrometry-based detection and antibody sequencing of Monoclonal Gammopathy of Undetermined Significance from patient serum - a case study.

W. Peng, M. A. den Boer, S. Tamara…·J. Snijder

This paper detects MGUS using LC-MS and determines M-protein sequences from serum, providing molecular detail for monoclonal gammopathies.

DOI 10.1021/acs.jproteome.3c00330

humanproteomics

ImmunologybioRxivApr 8, 2022

Humans have distinct repertoires of IgA1

K. Dingess, M. Hoek, D. van Rijswijck…·A. J. R. Heck

This study identifies two distinct structural populations of IgA1 in human serum and milk, with different clonal repertoires and origins.

DOI 10.1038/s41423-022-00954-2

humanproteomics

MicrobiologybioRxivJan 21, 2022

Promoting Fc-Fc interactions between anti-capsular antibodies provides strong complement-dependent immune protection against Streptococcus pneumoniae

L. Aguinagalde, M. A. den Boer, S. Castenmiller…·S. Rooijakkers

This paper shows that modifying anti-capsular antibodies to enhance hexamerization improves complement activation and immune protection against Streptococcus pneumoniae.

DOI 10.7554/elife.80669

MicrobiologybioRxivJul 20, 2020

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation

A. R. Cruz, M. A. den Boer, J. Strasser…·S. H. M. Rooijakkers

This study shows Staphylococcal protein A inhibits IgG hexamer formation, blocking complement activation, but IgG3 can still induce complement activation despite SpA.

DOI 10.1073/pnas.2016772118

humanproteomics