Selection for synchronized replication of genes encoding the same protein complex during tumorigenesis
Y. Chen, K. Li, X. Chu, L. B. Carey, W. Qian
The paper shows that genes encoding the same protein complex replicate synchronously in fast-proliferating cells like cancer cells to maintain stoichiometry, but not in slow-proliferating cells.
bioRxiv · Dec 13, 2018Evolutionary Biology