W. Qian

Overriding Mendelian inheritance in Arabidopsis with a CRISPR toxin-antidote gene drive that impairs pollen germination

This study develops a CRISPR-based gene drive in Arabidopsis to override Mendelian inheritance by targeting pollen germination, achieving high transmission rates with minimal resistance.

Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae post COVID-19

This study compares single-cell RNA sequencing data from human and mouse PASC samples to identify IFN-γ as a driver of respiratory sequelae post COVID-19.

Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19

This study identifies dysregulated immune-epithelial progenitor interactions in post-viral lung sequelae and shows that targeting IFN-γ, TNF, or IL-1β improves alveolar regeneration and pulmonary function.

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

TRAF4 is crucial for the propagation of ST2+ memory Th2 cells in IL-33-mediated type 2 airway inflammation

This study shows TRAF4 is essential for ST2+ memory Th2 cell proliferation in IL-33-driven type 2 airway inflammation, revealing its role in AKT/mTOR and ERK1/2 signaling and gene expression.

Heavy metal pollution characteristics of soil around a copper-nickel mine tailings pond in the northwest arid area of China and evaluation of desert phytoremediation potential

This study evaluates heavy metal pollution in soil near a copper-nickel mine tailings pond and assesses the phytoremediation potential of desert plants.

A Deep Redox Proteome Profiling Workflow and Its Application to Skeletal Muscle of a Duchene Muscular Dystrophy Model

The paper introduces a deep redox proteome profiling workflow and applies it to skeletal muscle from mdx mice, revealing increased thiol oxidation and pathway-specific effects.

Rotations improve the diversity of rhizosphere soil bacterial communities, enzyme activities and tomato yield

This study shows that rotating tomato with eggplant or arrowhead improves rhizosphere bacterial diversity, enzyme activity, and tomato yield and quality while reducing nitrate content.

Metabolomics and transcriptomics reveal the response mechanisms of Mikania micrantha to Puccinia spegazzinii infection

This study investigates how Mikania micrantha responds to Puccinia spegazzinii infection using metabolomics and transcriptomics, identifying changes in metabolites and gene expression.

BDSF is a degradation-prone quorum-sensing signal detected by the histidine kinase RpfC of Xanthomonas campestris pv. campestris

This study identifies BDSF as a degradation-prone quorum-sensing signal in Xanthomonas campestris pv. campestris, detected by RpfC, with lower physiological activity than DSF due to RpfB-mediated degradation.

Evidence for a mouse origin of the SARS-CoV-2 Omicron variant

The paper investigates the origin of the SARS-CoV-2 Omicron variant, finding evidence suggesting it jumped from humans to mice and then back to humans.

Activating mGlu3 metabotropic glutamate receptors rescues schizophrenia-like cognitive deficits through metaplastic adaptations within the hippocampus.

This study shows that activating mGlu3 receptors in hippocampal pyramidal cells improves cognitive function in mice by inducing metaplastic changes that enhance synaptic plasticity.

Sclerotinia sclerotiorum hijacks copper from its host for infection

This study identifies copper hijacking by Sclerotinia sclerotiorum during infection and shows host resistance mechanisms involving copper homeostasis.

TLR5 participates in the TLR4 receptor complex and biases towards MyD88-dependent signaling in environmental lung injury

This study shows TLR5 associates with TLR4 and biases its signaling toward MyD88 in lung injury responses to LPS, hyaluronan, and O3.

A novel deep learning scheme for morphology-based classification of mycobacterial infection in unstained macrophages

This paper develops a deep learning scheme to classify M. marinum-infected and uninfected macrophages based on morphology, achieving high accuracy at early infection stages.

Selection for synchronized replication of genes encoding the same protein complex during tumorigenesis

The paper shows that genes encoding the same protein complex replicate synchronously in fast-proliferating cells like cancer cells to maintain stoichiometry, but not in slow-proliferating cells.