Nuclear receptor subfamily 4A signaling as a key disease pathway of CD1c+ dendritic cell dysregulation in systemic sclerosis
N. H. Servaas, S. Hiddingh, E. Chouri, C. G. K. Wichers, A. J. Affandi, A. Ottria, C. P. J. Bekker, M. Cossu, S. Silva-Cardoso, M. van der Kroef, A. C. Hinrichs, T. Carvalheiro, N. Vazirpanah, L. Beretta, M. Rossato, , A. Pandit
This study identifies NR4A nuclear receptor subfamily genes as key regulators of immune and fibrosis pathways in SSc cDC2s through transcriptomic and network analysis, with functional validation using ChIP-sequencing and in vitro experiments.
bioRxiv · Nov 8, 2021Immunology