Author

S. Hiddingh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Pandit· 2 shared J. H. de Boer· 2 shared J. J. W. Kuiper· 2 shared M. van der Kroef· 2 shared T. Radstake· 2 shared A. C. Hinrichs· 1 shared A. D. Hollander· 1 shared A. J. Affandi· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

A. Pandit

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis

S. Hiddingh, A. Pandit, F. Verhagen, R. Rijken, N. Servaas, R. Komer-Wichers, N. t. Dam-van Loon, S. S. Imhof, T. Radstake, J. H. de Boer, J. J. W. Kuiper

The paper identifies CX3CR1-positive type 3 dendritic cells as implicated in non-infectious uveitis through transcriptome network analysis and flow cytometry.

bioRxiv · Nov 16, 2021Immunology

Nuclear receptor subfamily 4A signaling as a key disease pathway of CD1c+ dendritic cell dysregulation in systemic sclerosis

N. H. Servaas, S. Hiddingh, E. Chouri, C. G. K. Wichers, A. J. Affandi, A. Ottria, C. P. J. Bekker, M. Cossu, S. Silva-Cardoso, M. van der Kroef, A. C. Hinrichs, T. Carvalheiro, N. Vazirpanah, L. Beretta, M. Rossato, , A. Pandit

This study identifies NR4A nuclear receptor subfamily genes as key regulators of immune and fibrosis pathways in SSc cDC2s through transcriptomic and network analysis, with functional validation using ChIP-sequencing and in vitro experiments.

bioRxiv · Nov 8, 2021Immunology

ERAP2 increases the abundance of a peptide submotif highly selective for the Birdshot Uveitis-associated HLA-A29

W. Venema, S. Hiddingh, J. H. de Boer, F. Claas, A. Mulder, A. D. Hollander, E. Stratikos, S. Sarkizova, L. v. d. Veken, G. Janssen, P. v. Veelen, J. J. Kuiper

The paper investigates how ERAP2 affects HLA-A29 peptide presentation in BU and identifies an HLA-A29-specific peptide motif linked to autoantigens.

bioRxiv · Aug 14, 2020 · PreprintImmunology

Inhibitory CD200-receptor signaling is rewired by type I interferon

M. van der Vlist, M. I. Pascoal Ramos, L. L. van den Hoogen, S. Hiddingh, L. Timmerman, T. A. P. de Hond, E. D. Kaan, M. van der Kroef, R. J. Lebbink, F. M. A. Peters, W. Khoury-Hanold, R. Fritsch-Stork, T. Radstake, L. Meyaard

This study shows that type I interferon alters CD200R signaling by promoting RasGAP cleavage, converting CD200R from an inhibitor to a potentiator of IFNG mRNA production in SLE patients.

bioRxiv · Feb 6, 2020Immunology