MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
E. Backx, E. Wauters, J. Baldan, M. Van Bulck, E. Michiels, Y. Heremans, D. L. De Paep, L. Bouwens, S. Goyama, M. Kurokawa, P. Jacquemin, I. Houbracken, I. Rooman
The paper identifies MECOM as a critical regulator that suppresses acinar cell death by enabling dedifferentiation under stress conditions in both human and mouse models.
bioRxiv · Aug 21, 2020Cancer Biology