Author

E. Michiels

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

F. Rousseau· 2 shared J. Schymkowitz· 2 shared M. Ramakers· 2 shared A. D. Gitler· 1 shared A. S. Holehouse· 1 shared A. Siekierska· 1 shared A. van den Broeck· 1 shared A. Vanderstichele· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiophysics

F. Rousseau

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

N. N. Louros, M. Ramakers, E. Michiels, K. Konstantoulea, C. Morelli, T. Garcia, S. D'Haeyer, V. Goossens, D. Audenaert, F. Rousseau, J. Schymkowitz

The paper identifies sequence-specific rules governing heterotypic amyloid interactions and shows how they can modify amyloid assembly and contribute to neurodegenerative disease progression.

bioRxiv · Jun 4, 2021Biophysics

The tumor suppressor protein PTEN undergoes amyloid-like aggregation in tumor cells.

F. Claes, E. Maritschnegg, G. De Baets, A. Siekierska, M. Saiz Rubio, M. Ramakers, E. Michiels, F. De Smet, J. Depreeuw, I. Vergote, A. Vanderstichele, A. van den Broeck, S. Olbrecht, E. Hermans, F. Amant, , J. Schymkowitz

This study shows PTEN, a tumor suppressor, undergoes amyloid-like aggregation in tumor cells, both due to mutations and dysregulated protein homeostasis, and links this aggregation to poor clinical outcomes.

bioRxiv · Nov 30, 2020 · PreprintCancer Biology

MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions

E. Backx, E. Wauters, J. Baldan, M. Van Bulck, E. Michiels, Y. Heremans, D. L. De Paep, L. Bouwens, S. Goyama, M. Kurokawa, P. Jacquemin, I. Houbracken, I. Rooman

The paper identifies MECOM as a critical regulator that suppresses acinar cell death by enabling dedifferentiation under stress conditions in both human and mouse models.

bioRxiv · Aug 21, 2020Cancer Biology

Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress.

Y. Dorone, S. Boeynaems, B. Jin, F. Bossi, E. Flores, E. Lazarus, E. Michiels, M. De Decker, P. Baatsen, A. S. Holehouse, S. Sukenik, A. D. Gitler, S. Y. Rhee

This study identifies FLOE1, a prion-like protein in Arabidopsis thaliana, whose hydration-dependent phase separation regulates seed germination under water stress.

bioRxiv · Aug 7, 2020 · PreprintCell Biology