F. X. Real

Comprehensive Landscape of Non-muscle Invasive Bladder Cancer Tumour Microenvironment and Prognostic value of Cancer-Associated Myofibroblasts

The paper analyzes the tumor microenvironment of NMIBC, finding that cancer-associated myofibroblasts are prognostic markers for progression and recurrence.

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma

This study shows that low GATA4 and GATA6 expression in pancreatic ductal adenocarcinoma (PDAC) is linked to worse patient outcomes and loss of the classical tumor phenotype.

NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and suppresses PDAC initiation

This study identifies NFIC as a regulator of acinar cell differentiation and ER stress, showing its role in suppressing pancreatic ductal adenocarcinoma initiation.

A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer

This paper identifies a GATA6-centered gene regulatory network involving HNFs and ΔNp63 that controls plasticity and immune escape in pancreatic cancer, showing GATA6 loss is necessary but not sufficient for the basal phenotype.

Discovery and 3D imaging of a novel {triangleup}Np63-expressing basal cell type in human pancreatic ducts with implications in disease

The paper identifies a novel {Delta}Np63-expressing basal cell type in human pancreatic ducts and develops a 3D imaging method to study its role in disease.

STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cells

This study investigates how STAG2 loss-of-function affects genomic contacts and urothelial differentiation in bladder cancer cells, finding that STAG2 is critical for DNA looping that sustains luminal differentiation.

Immunohistochemistry-based taxonomical classification of bladder cancer predicts response to neoadjuvant chemotherapy

This paper shows that immunohistochemical classification of bladder cancer tumors predicts response to neoadjuvant chemotherapy, with BASQ-like tumors showing higher likelihood of complete response.

The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

The paper investigates the context-dependent oncogenic effects of the GATA3 X308_Splice mutation in breast cancer, showing its differential impact based on hormonal status.

A consensus molecular classification of muscle-invasive bladder cancer

The paper identifies six consensus molecular classes of muscle-invasive bladder cancer using transcriptomic data and classification systems, providing a framework for future biomarker validation.

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

The paper identifies a synthetic lethal relationship between STAG1 and STAG2 in cancers, showing STAG1 inactivation selectively targets STAG2-mutated cancer cells.