Author

S. Goyama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. Kurokawa· 2 shared T. Kitamura· 2 shared T. Shibata· 2 shared A. Huang· 1 shared A. M. Y. Zhang· 1 shared A. Tojo· 1 shared C. Deng· 1 shared C. J. Okumura· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

M. Kurokawa

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia

J. Nakahara, K. Yamamoto, T. Yabushita, T. Chinen, K. Ito, Y. Takeda, D. Kitagawa, S. Goyama

The paper identifies lineage-specific therapeutic vulnerabilities in AML subtypes using a two-group comparison approach based on genetic data from the Cancer Dependency Map.

bioRxiv · May 18, 2023 · PreprintCancer Biology

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

K. Miyake, T. Shibata, R. Sato, M. Taoka, S.-I. Saitoh, M. Komine, K. Yamaguchi, S. Goyama, Y. Motoi, J. Kitaura, K. Izawa, Y. Yamauchi, Y. Tsukamoto, T. Ichinohe, E. Fujita, , T. Taguchi

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

bioRxiv · Oct 27, 2022Immunology

Prospective isolation of mouse and human hematopoietic stem cells using Plexin domain containing 2

Y. Tanaka, Y. Kubota, I. Lieberam, J. L. Barlow, J. W. Bramley, C. Sakuma, T. Shibata, M. Nakagawa, Y. Kurosawa, T. Maruyama, C. J. Okumura, T. Akuta, D. G. Kent, T. M. Jessell, S. Goyama, , T. Kitamura

This study identifies PLXDC2 as a marker for isolating hematopoietic stem cells (HSCs) in both mouse and human, showing its utility in transplantation and xenograft models.

bioRxiv · Sep 27, 2021 · PreprintCell Biology

MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions

E. Backx, E. Wauters, J. Baldan, M. Van Bulck, E. Michiels, Y. Heremans, D. L. De Paep, L. Bouwens, S. Goyama, M. Kurokawa, P. Jacquemin, I. Houbracken, I. Rooman

The paper identifies MECOM as a critical regulator that suppresses acinar cell death by enabling dedifferentiation under stress conditions in both human and mouse models.

bioRxiv · Aug 21, 2020Cancer Biology

PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response

J. Ye, A. Huang, H. Wang, A. M. Y. Zhang, X. Huang, Q. Lan, T. Sato, S. Goyama, M. Kurokawa, C. Deng, M. Sander, D. F. Schaeffer, W. Li, J. L. Kopp, R. Xie

This study shows PRDM3 suppresses pancreatitis and pancreatic tumorigenesis by modulating inflammation and Kras-driven oncogenesis in acinar cells.

bioRxiv · Dec 18, 2019Cancer Biology