I. Rooman

Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after Total Neoadjuvant Therapy including Stereotactic Body Radiotherapy

This study shows that combining FOLFIRINOX with stereotactic body radiotherapy remodels pancreatic ductal adenocarcinoma, improving stromal and metabolic features and prognosis.

A single-cell atlas of the murine pancreatic ductal tree identifies novel cell populations with potential implications in pancreas regeneration and exocrine pathogenesis.

This study identifies 15 novel ductal cell populations in the mouse pancreas using scRNA-seq and investigates their roles in regeneration and exocrine pathogenesis.

MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions

The paper identifies MECOM as a critical regulator that suppresses acinar cell death by enabling dedifferentiation under stress conditions in both human and mouse models.

Discovery and 3D imaging of a novel {triangleup}Np63-expressing basal cell type in human pancreatic ducts with implications in disease

The paper identifies a novel {Delta}Np63-expressing basal cell type in human pancreatic ducts and develops a 3D imaging method to study its role in disease.

Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice

This study shows that combining nicotinamide with gemcitabine reduces pancreatic tumor growth and improves survival in mice by modulating the immune microenvironment.