S. Martens

Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

This study identifies NAP1 and SINTBAD as regulators of mitophagy, inhibiting OPTN-driven initiation while promoting NDP52-driven progression.

Generation and characterisation of an Arabidopsis thaliana f3h/fls1/ans triple mutant that accumulates eriodictyol derivatives

The paper generates and characterizes an Arabidopsis thaliana triple mutant lacking F3H, FLS1, and ANS, revealing a bypass pathway that leads to eriodictyol derivative accumulation.

Faa1 membrane binding drives positive feedback in autophagosome biogenesis via fatty acid activation

The paper shows Faa1 binds membranes to activate fatty acids, promoting autophagosome biogenesis through a positive feedback loop.

Transcriptomic and DNA methylation modifications during fruit ripening and in response to ABA treatment in sweet cherry

This study examines transcriptomic and DNA methylation changes in sweet cherry during ripening and in response to ABA treatment, revealing gene expression and epigenetic modifications related to ripening processes.

Unconventional Initiation of PINK1/Parkin Mitophagy by Optineurin

This study identifies an unconventional mechanism by which OPTN initiates mitophagy through TBK1 and the class III phosphatidylinositol 3-kinase complex I, distinct from the FIP200-ULK1/2 pathway.

Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery

The paper investigates how the LC3 lipidation machinery interacts with curved membranes during autophagy initiation, showing that ATG12-5-16L1 stabilizes membrane curvature.

Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy

The paper shows that non-canonical shuffled ATG8 interacting motifs in C53 link UFMylation and autophagy, revealing an ancestral regulatory mechanism for ER homeostasis.

Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy

This study investigates how different cargo receptors stimulate LC3 lipidation in selective autophagy using GUVs and shows varying requirements for autophagy core complexes.

NBR1 directly promotes the formation of p62 - ubiquitin condensates via its PB1 and UBA domains

This study shows NBR1 promotes p62-ubiquitin condensate formation through its PB1 and UBA domains, and its depletion reduces condensate formation in cells.

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

The paper identifies C53 as a conserved ER-phagy receptor that links autophagy with ribosome-associated quality control during ER stress in plants and mammals.

Discovery and 3D imaging of a novel {triangleup}Np63-expressing basal cell type in human pancreatic ducts with implications in disease

The paper identifies a novel {Delta}Np63-expressing basal cell type in human pancreatic ducts and develops a 3D imaging method to study its role in disease.

FIP200 organizes the autophagy machinery at p62-ubiquitin condensates beyond activation of the ULK1 kinase

This study shows FIP200 is necessary for phosphatidylinositol 3-phosphate formation and WIPI2 recruitment, and spatially organizes ATG13 and ATG9A for autophagosome formation at p62 condensates, despite ULK1 kinase activity not being strictly required.

A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy

The paper reconstitutes autophagy-related reactions and shows that a positive feedback loop between PI3KC3-C1 and WIPI2 accelerates LC3 lipidation.