Acidosis, Zinc and HMGB1 in Sepsis: A Common Connection Involving Sialoglycan Recognition
S. S. Siddiqui, C. Dhar, V. Sundaramurthy, A. Sasmal, H. Yu, E. Bandala-Sanchez, M. Li, X. Zhang, X. Chen, L. C. Harrison, D. Xu, A. Varki
This study shows that HMGB1 is sequestered by plasma sialoglycoproteins at physiological pH but is released during sepsis when pH and zinc levels drop, leading to immune activation.
Proceedings of the National Academy of Sciences · Mar 3, 2021Peer-reviewedImmunology